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Biochemical and structural abnormalities of the connective tissue in Larsen's syndrome.

Authors
  • Cetta, G
  • Lenzi, L
  • Ruggeri, A
  • Tenni, R
  • Boni, M
Type
Published Article
Journal
International orthopaedics
Publication Date
Jan 01, 1979
Volume
3
Issue
1
Pages
47–53
Identifiers
PMID: 549865
Source
Medline
Language
English
License
Unknown

Abstract

Skin, iliac crest cartilage and tendon of a patient affected with Larsen's syndrome were subjected to biochemical and ultrastructural investigation. A substantial increase in the ratio of glucosamine to galactosamine was found both in skin and cartilage. Ultrastructural abnormalities of collagen fibres and proteoglycan filaments were also found in Larsen's tissues. The significance of these findings are discussed.

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