Affordable Access

[Biochemical properties and clinical significance of protein glycation products].

Authors
  • Staniszewska, Magdalena
  • Gamian, Andrzej
Type
Published Article
Journal
Postȩpy higieny i medycyny doświadczalnej
Publication Date
Jan 01, 2003
Volume
57
Issue
2
Pages
123–147
Identifiers
PMID: 12866352
Source
Medline
License
Unknown

Abstract

Advanced glycation end-products (AGEs) are formed during non-enzymatic glycation--the process occurring in vitro and in the organism. The glycation products accumulate in tissues and interact with specific receptors, what induces various cellular responses. Some enzymes important in metabolism can be also glycated. The disturbances of homeostasis, related to the glycation products, are the reason for complications observed in diabetes and aging processes. There are presented in this paper: mechanism of the formation of AGEs, their cellular receptor (RAGE), as well as the effects of glycation in aging, diabetes and Alzheimer disease. Finally, there are described the compounds which could be useful as inhibitors of glycation in clinical practice.

Report this publication

Statistics

Seen <100 times