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Biochemical and physico-chemical aspects of biomaterials calcification.

Authors
  • Krasovskaya, S M1
  • Uzhinova, L D
  • Andrianova MYu,
  • Prischenko, A A
  • Livantsov, M V
  • Lomonosov, M V
  • 1 USSR Academy of Medical Sciences, Department of Cardiac Surgery, Moscow. , ()
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Nov 01, 1991
Volume
12
Issue
9
Pages
817–820
Identifiers
PMID: 1764551
Source
Medline
Language
English
License
Unknown

Abstract

Intrinsic tissue calcification mainly results from increased penetration of plasma proteins into the leaflets of bioprosthetic cardiac valves. The loss of activity of natural calcification inhibitors changes tissue properties and promotes pathological processes. N-vinylpyrrolidone, 3-amino-1,1-hydroxypropylendiphosphonic acid, O,O-diethylvinylphosphonates and antiaggregant (acryloilsalicylic acid) were used to decrease porosity and prevent calcification. gamma-radiation and glutaraldehyde were used to immobilize these agents. Tissue calcification was studied using subcutaneous implantation of the samples in young rats. The study indicates that the copolymerization of N-vinylpyrrolidone, O,O-diethylvinylphosphonates and acryloilsalicylic acid decreases calcium and phosphorous accumulation during in vivo experiments.

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