Affordable Access

deepdyve-link
Publisher Website

[Biochemical markers of bone turnover. New aspect. Metabolic bone markers in osteogenesis imperfecta].

Authors
  • Tanaka, Hiroyuki
Type
Published Article
Journal
Clinical calcium
Publication Date
Aug 01, 2009
Volume
19
Issue
8
Pages
1142–1147
Identifiers
DOI: CliCa090811421147
PMID: 19638698
Source
Medline
License
Unknown

Abstract

Osteogenesis imperfecta (OI) is a heterogeneous group of rare inherited bone and connective tissue disorders resulting from defect in collagen synthesis or function. It is characterized by bone fragility, which shows wide range of severities. The heterozygous mutations in the genes coding type I collagen are responsible to 80% of the OI cases. Metabolic bone markers relating type I collagen production or degraded products of mature collagen fiber may provides important information on the pathophysiology of OI. Typically, P1NP which is bone formation marker shows significant reduction and CTX or NTX shows relatively high level in type I OI. The other applications of metabolic bone markers in the management of OI will be discussed.

Report this publication

Statistics

Seen <100 times