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Biochemical and cytochemical analyses of BNP-stimulated guanylate cyclase in frog choroid plexus.

Authors
  • Vagnetti, D
  • Tei, S
  • Secca, T
  • Santarella, B
  • Roscani, C
  • Farnesi, R M
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Dec 24, 1995
Volume
705
Issue
1-2
Pages
295–301
Identifiers
PMID: 8821760
Source
Medline
License
Unknown

Abstract

This study shows that in the choroid plexus of Rana esculenta particulate guanylate cyclase (GC) is appreciably stimulated by porcine brain natriuretic peptide (BNP). Ultracytochemical tests for GC show that BNP notably increases the enzymatic reaction product along the apical surfaces of the epithelial cells. It can therefore be hypothesized that the apical zone of the epithelial cells possess receptors which have a particular affinity for BNP produced in the central nervous system and dumped into the cerebrospinal fluid. These results, together with those of a previous study [32], confirm that the choroid plexus is an organ which has receptors for the natriuretic peptides which are involved in the processes of osmoregulation and the control of cerebrospinal fluid production.

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