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Bioavailable gluconate chelated stannous fluoride toothpaste meta-analyses: Effects on dentine hypersensitivity and enamel erosion.

Authors
  • West, Nicola X1
  • He, Tao2
  • Zou, Yuanshu3
  • DiGennaro, Joe4
  • Biesbrock, Aaron5
  • Davies, Maria6
  • 1 Periodontology, Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK. Electronic address: [email protected]
  • 2 Research & Development, The Procter & Gamble Company, Mason, OH, 45040, USA. Electronic address: [email protected]
  • 3 Research & Development, The Procter & Gamble Company, Mason, OH, 45040, USA. Electronic address: [email protected]
  • 4 Research & Development, The Procter & Gamble Company, Mason, OH, 45040, USA. Electronic address: [email protected]
  • 5 Research & Development, The Procter & Gamble Company, Mason, OH, 45040, USA. Electronic address: [email protected]
  • 6 Periodontology, Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK. Electronic address: [email protected]
Type
Published Article
Journal
Journal of dentistry
Publication Date
Feb 01, 2021
Volume
105
Pages
103566–103566
Identifiers
DOI: 10.1016/j.jdent.2020.103566
PMID: 33383100
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF2) toothpaste with control toothpastes for treatment of dentine hypersensitivity (DH) and enamel erosion. A Procter & Gamble Oral Care archive of clinical studies was reviewed from 2000 to 2020. Eligible studies were Randomised Controlled Trials (RCTs) investigating bioavailable gluconate-chelated SnF2 toothpaste efficacy compared to controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <2 months (DH); or by erosive toothwear (profilometry) from in-situ samples, duration 10-15 days. Two authors independently assessed eligibility and resolved disagreements by discussion. A meta-analysis was undertaken and Risk of Bias (RoB) assessed using the Cochrane collaboration RoB tool for randomized parallel-group and cross-over trials. Fourteen RCTs (1287 participants) assessed DH relief and Six RCTs (184 participants) enamel erosion protection. For DH SnF2 toothpastes provided a 57 % (evaporative air) and 142 % (tactile) benefit versus negative controls (sodium fluoride/monofluorophosphate, 8 studies; p < 0.001). Compared to positive controls (potassium nitrate or arginine, 6 studies), a 22 % advantage (p = 0.036) was seen for evaporative air. In erosion studies, SnF2 toothpastes provided an 83 % benefit versus control toothpastes (arginine or sodium fluoride; p < 0.001) with a change (95 %CI) in average surface profilometry level (μm) of -2.02(-2.85, -1.20). The use of these bioavailable SnF2 toothpastes, as part of a daily oral hygiene regimen, will provide patients with enamel erosion protection, combined with alleviation of DH pain when present, improving quality of life. Copyright © 2021 Elsevier Ltd. All rights reserved.

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