Affordable Access

Bioactive polymers 66. Theophylline retardation in xanthan-based hydrogels.

Authors
  • Dumitriu, S1
  • Dumitriu, M
  • 1 Polytechnic Institute of Jassy, Romania. , (Oman)
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Nov 01, 1991
Volume
12
Issue
9
Pages
821–826
Identifiers
PMID: 1764552
Source
Medline
Language
English
License
Unknown

Abstract

Xanthan has been reticulated with epichlorohydrin to obtain a hydrogel for use in drug retardation. The obtained gel shows swelling degrees up to 1000. Theophylline has been inserted by diffusion into this gel; concentrations around 150 mg theophylline/g dry hydrogel being obtained. Controlled release of theophylline has been established by elution in a close recirculation system. Zero-order kinetics has been obtained in the diffusion process of theophylline into the eluent, within a 14 h time interval.

Report this publication

Statistics

Seen <100 times