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Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B

Authors
  • liu, yayue
  • chen, senhua
  • liu, zhaoming
  • yongjun, lu
  • xia, guoping
  • liu, hongju
  • lei, he
  • she, zhigang
Publication Date
May 19, 2015
Identifiers
DOI: 10.3390/md13053091
OAI: oai:mdpi.com:/1660-3397/13/5/3091/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Chemical investigation of the endophytic fungus Aspergillus sp. 16-5B cultured on Czapek’s medium led to the isolation of four new metabolites, aspergifuranone (1), isocoumarin derivatives (±) 2 and (±) 3, and (R)-3-demethylpurpurester A (4), together with the known purpurester B (5) and pestaphthalides A (6). Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration of Compound 1 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra, and that of Compound 4 was revealed by comparing its optical rotation data and CD with those of the literature. The structure of Compound 6 was further confirmed by single-crystal X-ray diffraction experiment using CuKα radiation. All isolated compounds were evaluated for their α-glucosidase inhibitory activities, and Compound 1 showed significant inhibitory activity with IC50 value of 9.05 ± 0.60 μM. Kinetic analysis showed that Compound 1 was a noncompetitive inhibitor of α-glucosidase. Compounds 2 and 6 exhibited moderate inhibitory activities.

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