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Bioactive Diterpene Derivatives from the Marine Sponge Spongionella sp.

Authors
  • Rateb, Mostafa E.
  • Houssen, Wael E.
  • Schumacher, Marc
  • Harrison, William T. A.
  • Marc Diederich
  • Ebel, Rainer
  • Jaspars, Marcel
Type
Published Article
Journal
Journal of Natural Products
Publisher
American Chemical Society
Publication Date
Aug 22, 2009
Volume
72
Issue
8
Pages
1471–1476
Identifiers
DOI: 10.1021/np900233c
Source
LBMCC
Keywords
License
White

Abstract

Three new compounds of the rare classes trisnorditerpenes, bisnorditerpenes, and norditerpenes, gracilins J-L (1, 2, 6), and a new diterpene, 3'-norspongiolactone (8), were isolated from the extract of the marine sponge Spongionella sp. using NMR- and bioassay-guided fractionation, in addition to three known gracilins (3-5) as well as the known diterpenoid tetrahydroaplysulphurin-1 (7). The structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The structure of gracilin H (3) was confirmed by single-crystal X-ray analysis. All compounds were tested for their cytotoxicity and for their potential to inhibit EGF-R tyrosine kinase.

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