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Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms.

Authors
  • Yin, Jun-Fa1
  • Li, Ji-Fang-Tong1
  • Li, Xing-Hong2
  • Yang, You-Lin3
  • Qin, Zhan-Fen1
  • 1 State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center of Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, 18 Shuangqing Road, Haidian District, Beijing 100085, PR China; University of the Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, PR China. , (China)
  • 2 State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center of Eco-Environmental Sciences, Chinese Academy of Sciences, PO Box 2871, 18 Shuangqing Road, Haidian District, Beijing 100085, PR China; University of the Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, PR China. Electronic address: [email protected] , (China)
  • 3 The First People's Hospital of Wenling, 333 Chuang'annan Road, Chengxi Street, Taizhou 317500, Zhejiang Province, PR China. , (China)
Type
Published Article
Journal
The Science of the total environment
Publication Date
Jan 15, 2020
Volume
700
Pages
134391–134391
Identifiers
DOI: 10.1016/j.scitotenv.2019.134391
PMID: 31627044
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In this study, bioaccumulation and transfer characteristics of dechlorane plus (DP) were examined between human adipose tissue and matched maternal serum, and the possible transfer mechanism between tissues was further discussed. The median level of total DP was 971 pg g-1 wet weight (ww) and 1.22 ng g-1 lipid weight (lw) in adipose tissue, respectively, and was 34.7 pg g-1 ww and 3.98 ng g-1 lw for serum, respectively. DP wet levels' positive association with fat contents of five types of human tissues indicated that DP distribution might be related to lipid-driven mechanism. However, the lipid-adjusted adipose-serum partitioning ratios were estimated to be 0.35 for syn-DP and 0.35 for anti-DP, accordingly, which implied that the DP distribution between serum and adipose tissues, was not only regulated by the tissue lipid contents. Both the internal mono-dechlorination of anti-DP, and stereo-selective behavior of DP isomers were not found in DP transfer from blood to adipose tissue. The marginal positive relationship was observed between serum levels and apolipoprotein A concentrations (p = 0.095 for total DP and 0.045 for syn-DP), and neither association was found between serum levels and thyroid hormone concentrations (THs). To our best knowledge, this is the first report about the accumulation relationship of DP between human adipose tissue and blood stream with the corresponding distribution-related mechanism. Copyright © 2019 Elsevier B.V. All rights reserved.

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