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Bio-antimutagenic effect of L-cysteine on diiodohydroxyquinoline-induced micronuclei in Swiss mice.

Authors
  • Ghaskadbi, S
  • Pavaskar, S V
  • Vaidya, V G
Type
Published Article
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publisher
Elsevier
Publication Date
Apr 01, 1987
Volume
187
Issue
4
Pages
219–222
Identifiers
PMID: 3104778
Source
Medline
License
Unknown

Abstract

The mutagenic potential of diiodohydroxyquinoline (DIHQ), a common anti-amebic drug, was tested using the in vivo micronucleus test in Swiss mice following oral administration. It was found to be mutagenic in a dose-dependent manner. Using the same model system, the bio-antimutagenic effect of the sulfhydryl compound L-cysteine against DIHQ was established.

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