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The binding of protein A of immunoglobulin G and of Fab and Fc fragments.

Authors
  • Endresen, C
Type
Published Article
Journal
Acta pathologica et microbiologica Scandinavica. Section C, Immunology
Publication Date
Jun 01, 1979
Volume
87C
Issue
3
Pages
185–189
Identifiers
PMID: 484238
Source
Medline
License
Unknown

Abstract

Results are presented to show that protein A (pA) may fix to the Fab region of IgG outside the antigen binding site. Thus, pA-reactive Fab fragments were isolated both from specific anti-egg albumin and specific anti-measles virus antibodies. A probable significance of this Fab reactivity in the precipitation reaction between IgG and pA is discussed. Reactive IgG from human, guinea pig, rabbit, and porcine normal sera all showed similar avidity towards pA. Slight differences between IgG subclasses were, however, observed. The avidity of pA-reactive Fab and Fc fragments, isolated from normal porcine IgG, was highest in the latter.

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