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Binding of adult T-cell leukemia virus to various hematopoietic cells.

Authors
  • Yamamoto, N
  • Chosa, T
  • Koyanagi, Y
  • Tochikura, T
  • Schneider, J
  • Hinuma, Y
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 1984
Volume
21
Issue
3
Pages
261–268
Identifiers
PMID: 6318970
Source
Medline
License
Unknown

Abstract

A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negative T-cell line, CCRF-CEM cells. When the viruses were pre-incubated with anti-ATLV-positive human sera, ATLV binding to the cells was clearly inhibited but not by pre-incubation with anti-ATLV-negative sera. These data suggest that: (1) ATLV binds not only to T-cells but also to multiple types of cells of hematopoietic origin; (2) anti-ATLV antibody-positive human sera have the blocking antibody for the binding of ATLV to lymphoid cells.

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