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Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.

Authors
  • Yoon, Jung-Hwan1
  • Higuchi, Hajime
  • Werneburg, Nathan W
  • Kaufmann, Scott H
  • Gores, Gregory J
  • 1 Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA.
Type
Published Article
Journal
Gastroenterology
Publisher
Elsevier
Publication Date
Apr 01, 2002
Volume
122
Issue
4
Pages
985–993
Identifiers
PMID: 11910351
Source
Medline
License
Unknown

Abstract

The results show that EGFR is activated by bile acids and functions to induce COX-2 expression by an MAPK cascade. This induction of COX-2 may participate in the genesis and progression of cholangiocarcinomas.

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