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Bilateral enlargement of all extraocular muscles: a presenting ophthalmic sign of hematologic malignancy.

Authors
  • McCoskey, Makayla1
  • Reshef, Edith R1
  • Wolkow, Natalie1, 2
  • Yoon, Michael K1
  • 1 Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
  • 2 Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Eye and Ear, Harvard Medical SchoolDavid G. , Boston, Massachusetts, USA.
Type
Published Article
Journal
Orbit (Amsterdam, Netherlands)
Publication Date
Feb 01, 2024
Volume
43
Issue
1
Pages
160–163
Identifiers
DOI: 10.1080/01676830.2022.2090014
PMID: 35734822
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Hematologic malignancies such as leukemia and lymphoma can frequently present in the orbit; however, involvement of the extraocular muscles is rare. The authors report two cases of systemic hematologic malignancy presenting with bilateral extraocular muscle enlargement and associated compressive optic neuropathy (CON). Both patients experienced clinical and radiographic improvement of ocular and systemic manifestations of disease with prompt initiation of targeted chemotherapy. These cases highlight the importance of including hematologic malignancy in the differential diagnosis of atypical bilateral extraocular muscle enlargement.

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