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Biglycan expression in current cigarette smokers: a possible link between active smoking and atherogenesis.

Authors
  • Mandraffino, G1
  • Imbalzano, E2
  • Mamone, F2
  • Aragona, C O2
  • Lo Gullo, A2
  • D'Ascola, A3
  • Alibrandi, A4
  • Cinquegrani, A2
  • Mormina, E5
  • Versace, A2
  • Basile, G2
  • Sardo, M A2
  • Cinquegrani, M2
  • Carerj, S2
  • Saitta, A2
  • 1 Department of Clinical and Experimental Medicine, University of Messina, Italy. Electronic address: [email protected] , (Italy)
  • 2 Department of Clinical and Experimental Medicine, University of Messina, Italy. , (Italy)
  • 3 Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Italy. , (Italy)
  • 4 Department of Statistics, University of Messina, Italy. , (Italy)
  • 5 Department of Biomedical Sciences and of Morphologic and Functional Images, University of Messina, Italy. , (Italy)
Type
Published Article
Journal
Atherosclerosis
Publication Date
Dec 01, 2014
Volume
237
Issue
2
Pages
471–479
Identifiers
DOI: 10.1016/j.atherosclerosis.2014.10.024
PMID: 25463076
Source
Medline
Keywords
License
Unknown

Abstract

BGN-mRNA was enhanced in young smokers, compared to controls, and appears associated to a proatherogenic profile, characterized by increased fibrinogen, CRP, and IL-6, lower HDL-C, altered AS and cIMT values, particularly in those with higher SEIx: the more cigarettes smoked over years, the more marked the alterations. Although we cannot state whether BGN have a direct causal role in inducing, maintaining and developing vascular damage, including intima-media wall thickening and arterial stiffening, our data could suggest that it may represent a link between proatherogenic status induced by cigarette smoking, and the development and progression of vascular damage.

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