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Bicluster and pathway enrichment analysis of HCV-induced cirrhosis and hepatocellular carcinoma.

Authors
  • Cheng, Peng
  • Cheng, You
  • Su, Mei X
  • Li, Dong
  • Zhao, Guo Z
  • Gao, Hui
  • Li, Yan
  • Zhu, Jie Y
  • Li, Hua
  • Zhang, Tao
Type
Published Article
Journal
Asian Pacific journal of cancer prevention : APJCP
Publication Date
Jan 01, 2012
Volume
13
Issue
8
Pages
3741–3745
Identifiers
PMID: 23098464
Source
Medline
License
Unknown

Abstract

The differentially expressed genes might be involved in hepatocarcinogenesis through upregulating the pathways of ECM-receptor interaction, focal adhesion, cell adhesion molecules and other cancer-related pathways, and downregulating the pathways of "complement and coagulation cascades". We hope our results could aid in seeking of therapeutic targets for HCV-induced hepatocellular carcinoma.

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