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BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.).

Authors
  • Jang, Gun-Hee1
  • Lee, Michael2
  • 1 Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 406-772, Republic of Korea. , (North Korea)
  • 2 Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 406-772, Republic of Korea. Electronic address: [email protected] , (North Korea)
Type
Published Article
Journal
Life sciences
Publication Date
Apr 25, 2014
Volume
102
Issue
1
Pages
41–48
Identifiers
DOI: 10.1016/j.lfs.2014.02.036
PMID: 24625733
Source
Medline
Keywords
License
Unknown

Abstract

Taken together, these results suggest that gossypol may exhibit potential for the treatment of BRAF inhibitor-resistant tumors, but a functional p21(Cip1) is a prerequisite for a positive response to its clinical application.

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