Affordable Access

Publisher Website

Structures, stabilities & conformational behaviors of hydrogen-atom abstractions of cytosine nucleosides: AIM & NBO analysis

Elsevier B.V.
Publication Date
DOI: 10.1016/j.comptc.2011.05.033
  • Dft Study
  • Sugar Puckering Mode
  • Cytosine Nucleosides
  • Hydrogen Atom Abstraction
  • Aim Theory
  • Biology
  • Engineering
  • Mathematics


Abstract Abstraction of hydrogen atom from DNA and RNA subunits leads to formation of a neutral radical. The formation of these radicals can lead to harmful structural alternations and formation of multiple lesions in helixes of DNA and RNA. In the present work, we explore theoretically energetic and structural properties of the possible radicals formed via hydrogen atom abstraction at various sites of sugar part of cytosine nucleosides by employing B3LYP exchange–correlation functional with 6-311++G (d,p) orbital basis sets. Two types of free radicals may be found by hydrogen abstraction of sugar part of cytosine nucleosides: carbon centered radicals and the oxygen centered radicals. The computation revealed 0–22.6 kcal/mol energy disparity in these radical. Radical-centered carbon increases the extent of bonding with its adjacent atoms. This tendency should be important in predicting the reactivity of sugar-based radicals. The hydrogen abstracted sugar radicals of cytosine nucleosides have following stability sequence: raC2 ′ > raC1 ′ > raC3 ′ > raC4 ′ > raC5 ′ > raO5 ′ > raO2 ′ > raO3 ′ for cytidine and radC1 ′ > radC2 ′ > radC4 ′ > radC3 ′ > radC5 ′ > radO5 ′ > radO3 ′ for deoxycytidine. Furthermore, to take into account the effect of solvent environment on the stability order of radicals integral equation formalism of the polarized continuum model (IEF-PCM) was employed to model aqueous solution. The role of CH⋯O and HO⋯H intramolecular hydrogen bonds in stability of radicals investigated based on results of topological properties of AIM theory. Moreover, variations of significant structural parameters such as puckering amplitudes and phase angles of sugar parts of cytosine nucleosides after radical formation are also found. These finding have several biological implications and may explain the possible degrees of damage to the DNA double strand.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Study of proper and improper hydrogen bonding usin...

on Journal of Molecular Structure Jan 01, 2004

Directionality of inter- and intramolecular OHO hy...

on The Journal of Physical Chemis... Aug 02, 2012

Stereoelectronic interaction effects on the confor...

on Journal of Molecular Graphics... Jan 01, 2010

GIAO, DFT, AIM and NBO analysis of the N-H...O int...

on Magnetic Resonance in Chemistr... September 2010
More articles like this..