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A convenient synthetic route to oligonucleotide conjugates

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
7
Issue
8
Identifiers
DOI: 10.1016/s0960-894x(97)00152-2

Abstract

Abstract The synthesis of oligodeoxyribonucleotide 13mers conjugated to cholic, folic, lipoic and pantothenic acids through thioether and disulphide bonds is described employing a convenient methodology which involves initial preparation of cysteinyl derivatives of the acids on solid phase.

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