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Detection of circulating tumor cells in bladder cancer patients

Authors
Journal
Cancer Treatment Reviews
0305-7372
Publisher
Elsevier
Publication Date
Volume
35
Issue
3
Identifiers
DOI: 10.1016/j.ctrv.2008.11.003
Keywords
  • Circulating Bladder Cancer Cells
  • Molecular Markers
  • Clinical Significance

Abstract

Summary The methods employed for the detection of circulating bladder cancer cells (CBCs) and their use as a molecular staging tool in clinical settings are thoroughly reviewed. CBC isolation and enrichment methods are discussed according to their advantages and pitfalls along with the clinical data of PCR-based techniques used for CBC detection. In addition, we review the specificity of molecular markers that have been proposed so far for CBC identification, and we comment on the controversial clinical data, proposing laboratory approaches which may improve the clinical significance of CBC detection in bladder cancer.

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