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Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

Authors
Publisher
BioMed Central Ltd.
Publication Date
Disciplines
  • Biology
  • Medicine

Abstract

We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

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