Affordable Access

T cell recognition of weak ligands: roles of signaling, receptor number, and affinity

  • Health Sciences
  • Immunology
  • T Cell
  • Altered Peptide Ligands
  • Intracellular Signaling
  • Viral Escape
  • Autoimmunity
  • Medicine


T cell recognition of antigen is a crucial aspect of the adaptive immune response. One of the most common means of pathogen immune evasion is mutation of T cell epitopes. T cell recognition of such ligands can result in a variety of outcomes including activation, apoptosis and anergy. The ability of a given T cell to respond to a specific peptide–MHC ligand is regulated by a number of factors, including the affinity, on- and off-rates and half-life of the TCR–peptide–MHC interaction. Interaction of T cells with low-potency ligands results in unique signaling patterns and requires engagement with a larger number of T cell receptors than agonist ligands. This review will address these aspects of T cell interaction with weak ligands and the ways in which these ligands have been utilized therapeutically.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times