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Experimental defibrination:II. Histological studies by light and electron microscopy

Authors
Journal
Microvascular Research
0026-2862
Publisher
Elsevier
Publication Date
Volume
1
Issue
3
Identifiers
DOI: 10.1016/0026-2862(69)90032-6
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The histological changes, observed by light microscopy, have been studied in the lung and kidney of experimental animals following recent defibrination by liquoid and thromboplastin. Essentially, these are the presence of intracapillary granular material irregularly giving a staining reaction for fibrin together with the presence in the capillaries of darkly staining bodies which we have termed “haematoxylinophil bodies”. A study of the glomerular ultrastructure under the same conditions has shown that these haematoxylinophil bodies are extruded endothelial cell nuclei. Although this phenomenon of extrusion is probably not specific for fibrin deposition, the appearance of numerous haematoxylinophil bodies associated with granular material in pulmonary and renal capillaries may provide a useful histological indicator for recent defibrination.

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