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Total synthesis of (±)-17-norcamptothecin, a novel E-ring modified camptothecin

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
66
Issue
35
Identifiers
DOI: 10.1016/j.tet.2010.06.003
Keywords
  • Total Synthesis
  • Camptothecin Analog
  • 17-Norcamptothecin

Abstract

Abstract The first total synthesis of (±)-17-norcamptothecin, a novel camptothecin analog possessing an α-hydroxy-γ-lactone E-ring, has been accomplished by using a short and flexible route. The stability of this new compound in aqueous medium has been evaluated through fluorescence spectroscopy.

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