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Direct detection of paramagnetic species in adriamycin perfused rat hearts

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
153
Issue
1
Identifiers
DOI: 10.1016/s0006-291x(88)81218-x

Abstract

Direct detection of paramagnetic species in control and adriamycin-perfused rat hearts has been carried out. Depending on the flow rate of the perfusion solution(8,4,2 and 1 ml/min) different paramagnetic species were observed: Fe(III)(g=2.12)at 4 ml/min; three types of oxygen centered radicals of which two in control hearts(g ‖ 1=2.05 g ‖ 2=2.038 g ⊥ 1=g ⊥ 2=2.008) and the third one (g ‖=2.03 g ⊥=2.005) in adriamycin perfused hearts, at 2 ml/min. The latter radical was the only one observed at perfusion rate of 1 ml/min both in control and adriamycin treated systems. A relationship between the intracellular enzymatic reductive activation of the anthracycline and the occurrence of ischemic conditions(4,2 and 1 ml/min) in myocardial tissues is proposed basing on the relative amounts of the paramagnetic species above mentioned.

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