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Beyond the 3+3 method: expanded algorithms for dose- escalation in Phase I oncology trials of two agents.

Authors
Type
Published Article
Journal
Clinical trials (London, England)
Publication Date
Volume
8
Issue
3
Pages
247–259
Identifiers
DOI: 10.1177/1740774511404091
PMID: 21730075
Source
Medline
License
Unknown

Abstract

Algorithmic A+B+C designs are potentially useful in the design of Phase I trials of combinations of two agents. However, a head-to-head comparison to model-based designs is needed to warrant their general use.

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