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Beta-blocker management in high-risk patients presenting for non-cardiac surgery: before and after the POISE Trial.

Authors
  • Leslie, K1
  • Myles, P S
  • Halliwell, R
  • Paech, M J
  • Short, T G
  • Walker, S
  • 1 Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Australia. [email protected] , (Australia)
Type
Published Article
Journal
Anaesthesia and intensive care
Publication Date
Mar 01, 2012
Volume
40
Issue
2
Pages
319–327
Identifiers
PMID: 22417028
Source
Medline
Language
English
License
Unknown

Abstract

The POISE Trial was a randomised, placebo-controlled, double-blind study of the effectiveness of perioperative beta-blockade in preventing cardiac events including death in 8351 patients. Our hypothesis was that knowledge of the results of the POISE Trial would either increase or decrease the use of effective perioperative beta-blockade, depending on the result. Patients presenting for non-cardiac surgery and at risk of perioperative cardiac events were recruited in two cohorts before and after the release of the POISE Trial results. Effective perioperative beta-blockade was defined as heart rate <65 beats per minute for at least 80% of the perioperative period in patients prescribed beta-blockers. Effective perioperative beta-blockade was achieved in 22 (11.5%) of 191 patients prescribed perioperative beta-blockade in the first cohort (n=392) and seven (6%) of 118 patients in the second cohort (n=241) (P=0.10). Effective heart rate control was achieved in 29 (9%) patients prescribed perioperative beta-blockers compared with 10 (3%) patients not prescribed perioperative beta-blockers (P=0.001). The rate of implementation of effective beta-blockade was low before POISE and this did not change significantly after publication. Our finding does not provide reliable evidence of a change in practice as a result of the POISE Trial.

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