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beta-Secretase inhibitor increases amyloid-beta precursor protein level in rat brain cortical primary neurons induced by okadaic acid.

Authors
Type
Published Article
Journal
Chinese medical journal
Publication Date
Volume
121
Issue
15
Pages
1439–1444
Identifiers
PMID: 18959123
Source
Medline

Abstract

In OA-induced tau phosphorylation cell model, inhibition of beta-secretase may protect neurons from death induced by OA. Because of increased accumulation of AbetaPP in neurons after OA treatment, more AbetaPP turns to be cleaved by beta-secretase, producing neurotoxic betaCTF. As apotential effective therapeutic target, beta-secretase is worth investigating further.

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