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beta-Secretase inhibitor increases amyloid-beta precursor protein level in rat brain cortical primary neurons induced by okadaic acid.

Authors
  • 1
  • 1 Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. , (China)
Type
Published Article
Journal
Chinese medical journal
Publication Date
Volume
121
Issue
15
Pages
1439–1444
Identifiers
PMID: 18959123
Source
Medline
License
Unknown

Abstract

In OA-induced tau phosphorylation cell model, inhibition of beta-secretase may protect neurons from death induced by OA. Because of increased accumulation of AbetaPP in neurons after OA treatment, more AbetaPP turns to be cleaved by beta-secretase, producing neurotoxic betaCTF. As apotential effective therapeutic target, beta-secretase is worth investigating further.

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