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beta-endorphin is a potent analgesic agent.

Authors
  • H H Loh
  • L F Tseng
  • E Wei
  • C H Li
Publication Date
Aug 01, 1976
Source
PMC
Keywords
License
Unknown

Abstract

beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, beta-endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of beta-endorphin in vivo is also compared to other peptides that show opiate-like activity in assays in vitro.

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