A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.
- Authors
- Type
- Published Article
- Journal
- Journal of Natural Products
- Publisher
- American Chemical Society
- Publication Date
- Feb 26, 2010
- Volume
- 73
- Issue
- 2
- Pages
- 255–257
- Identifiers
- DOI: 10.1021/np9005426
- PMID: 20000782
- Source
- Medline
- Language
- English
- License
- Unknown
Abstract
A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.