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A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.

Authors
  • Inman, Wayne D1
  • Bray, Walter M
  • Gassner, Nadine C
  • Lokey, R Scott
  • Tenney, Karen
  • Shen, Young Yongchun
  • Tendyke, Karen
  • Suh, Ted
  • Crews, Phillip
  • 1 Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.
Type
Published Article
Journal
Journal of Natural Products
Publisher
American Chemical Society
Publication Date
Feb 26, 2010
Volume
73
Issue
2
Pages
255–257
Identifiers
DOI: 10.1021/np9005426
PMID: 20000782
Source
Medline
Language
English
License
Unknown

Abstract

A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.

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