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Beraprost sodium, a stable prostacyclin analogue, elicits dilation of isolated porcine retinal arterioles: roles of eNOS and potassium channels.

Authors
  • Ono, Shinji
  • Nagaoka, Taiji
  • Omae, Tsuneaki
  • Tanano, Ichiro
  • Kamiya, Takayuki
  • Otani, Shinichi
  • Ishibazawa, Akihiro
  • Yoshida, Akitoshi
Type
Published Article
Journal
Investigative Opthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Sep 01, 2014
Volume
55
Issue
9
Pages
5752–5759
Identifiers
DOI: 10.1167/iovs.14-14902
PMID: 25082887
Source
Medline
Keywords
License
Unknown

Abstract

Beraprost sodium, a stable PGI2 analogue, causes vasodilation of the retinal arterioles mediated via the IP receptor. The current findings suggest that BPS elicits endothelium-dependent and -independent dilation of the retinal arterioles mediated by NO induced by activation of PKA in the endothelium and the KATP channel activation in the vascular smooth muscle, respectively.

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