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Benzophenone photoprobes for phosphoinositides, peptides and drugs.

Authors
  • Prestwich, G D
  • Dormán, G
  • Elliott, J T
  • Marecak, D M
  • Chaudhary, A
Type
Published Article
Journal
Photochemistry and Photobiology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 01, 1997
Volume
65
Issue
2
Pages
222–234
Identifiers
PMID: 9066302
Source
Medline
License
Unknown

Abstract

Benzophenones (BP) and related aryl ketone photophores have become established as the photoactivatable group of choice for high-efficiency covalent modification of hydrophobic regions of binding proteins, including enzymes and receptors that recognize peptide hormones, (oligo) nucleotides and nucleosides, phosphoinositides, inositol polyphosphates and a wide variety of therapeutic molecules. This review presents the advantages of BP as photoaffinity labels and provides specific examples from the last 3 years of applications of BP-containing ligands used in biochemistry.

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