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Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

  • Hox, Valerie1
  • Lourijsen, Evelijn2
  • Jordens, Arnout3
  • Aasbjerg, Kristian4
  • Agache, Ioana5
  • Alobid, Isam6, 7
  • Bachert, Claus3, 8
  • Boussery, Koen9
  • Campo, Paloma10
  • Fokkens, Wytske2
  • Hellings, Peter11
  • Hopkins, Claire12
  • Klimek, Ludger13
  • Mäkelä, Mika14
  • Mösges, Ralph15
  • Mullol, Joaquim6
  • Pujols, Laura6
  • Rondon, Carmen10
  • Rudenko, Michael16
  • Toppila-Salmi, Sanna14
  • And 7 more
  • 1 Cliniques Universitaires Saint-Luc Brussels, Av. Hippocrate 10, Brussels, 1200, Belgium , Brussels (Belgium)
  • 2 Amsterdam University Medical Centres, AMC, Amsterdam, The Netherlands , Amsterdam (Netherlands)
  • 3 Ghent University Hospital, Ghent, Belgium , Ghent (Belgium)
  • 4 Bispebjerg University Hospital, Copenhagen, Denmark , Copenhagen (Denmark)
  • 5 Transsylvania University, Brasov, Romania , Brasov (Romania)
  • 6 CEBERES Universitat de Barcelona, Catalonia, Spain , Catalonia (Spain)
  • 7 Centro Medico Teknon, Barcelona, Spain , Barcelona (Spain)
  • 8 Karolinska University Hospital, Stockholm, Sweden , Stockholm (Sweden)
  • 9 Ghent University, Ghent, Belgium , Ghent (Belgium)
  • 10 Hospital Regional Universitario of Málaga, IBIMA, ARADyAL, Malaga, Spain , Malaga (Spain)
  • 11 University Hospitals, Louvain, Belgium , Louvain (Belgium)
  • 12 Guy’s & St Thomas’ Hospital, London, UK , London (United Kingdom)
  • 13 Center of Rhinology and Allergology, Wiesbaden, Germany , Wiesbaden (Germany)
  • 14 Helsinki University Hospital and University of Helsinki, Helsinki, Finland , Helsinki (Finland)
  • 15 University of Cologne, Cologne, Germany , Cologne (Germany)
  • 16 London Allergy and Immunology Center, London, UK , London (United Kingdom)
  • 17 Royal National Throat, Nose and Ear Hospital, London, UK , London (United Kingdom)
  • 18 Medical University Graz, Graz, Austria , Graz (Austria)
  • 19 Heinrich-Heine-University, Düsseldorf, Germany , Düsseldorf (Germany)
  • 20 University of Groningen, Groningen, The Netherlands , Groningen (Netherlands)
Published Article
Clinical and Translational Allergy
Springer (Biomed Central Ltd.)
Publication Date
Jan 03, 2020
DOI: 10.1186/s13601-019-0303-6
Springer Nature


Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that—potentially severe—side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus document summarizing the benefits of systemic steroids for each upper airway disease type, as well as highlighting the potential harms of this treatment is currently lacking. Therefore, a panel of international experts in the field of Rhinology reviewed the available literature with the aim of providing recommendations for the use of systemic steroids in treating upper airway disease.

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