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Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility.

Authors
  • Hashimoto, Michinao
  • Langer, Robert
  • Kohane, Daniel S
Type
Published Article
Journal
Lab on a Chip
Publisher
The Royal Society of Chemistry
Publication Date
Jan 21, 2013
Volume
13
Issue
2
Pages
252–259
Identifiers
DOI: 10.1039/c2lc40888k
PMID: 23192674
Source
Medline
License
Unknown

Abstract

This paper describes a general scheme to fabricate microchannels from curable polymers on a laboratory benchtop. Using the scheme described here, benchtop fabrication of SU-8 microfluidic systems was demonstrated for the first time, and their compatibility with organic solvents was demonstrated. The fabrication process has three major stages: 1) transferring patterns of microchannels to polymer films by molding, 2) releasing the patterned film and creating inlets and outlets for fluids, and 3) sealing two films together to create a closed channel system. Addition of a PDMS slab supporting the polymer film provided structural integrity during and after fabrication, allowing manipulation of the polymer films without fracturing or deformation. SU-8 channels fabricated according to this scheme exhibited solvent compatibility against continuous exposure to acetone and ethylacetate, which are incompatible with native PDMS. Using the SU-8 channels, continuous generation of droplets of ethylacetate, and templated synthesis of poly (lactic-co-glycolic acid) (PLGA) microparticles, both with stable size, were demonstrated continuously over 24 h, and at intervals over 75 days.

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