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BEN: a novel domain in chromatin factors and DNA viral proteins.

Authors
  • Abhiman, Saraswathi
  • Iyer, Lakshminarayan M
  • Aravind, L
Type
Published Article
Journal
Bioinformatics (Oxford, England)
Publication Date
Feb 15, 2008
Volume
24
Issue
4
Pages
458–461
Identifiers
DOI: 10.1093/bioinformatics/btn007
PMID: 18203771
Source
Medline
License
Unknown

Abstract

We report a previously uncharacterized alpha-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or transcription.

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