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Behavioural sequelae of methaqualone in man and in the monkey (Macaca mulatta).

Authors
  • Borland, R G
  • Nicholson, A N
  • Wright, C M
Type
Published Article
Journal
British journal of clinical pharmacology
Publication Date
Apr 01, 1975
Volume
2
Issue
2
Pages
131–141
Identifiers
PMID: 825133
Source
Medline
License
Unknown

Abstract

1 Residual effects in man of methaqualone hydrochloride (400 mg) were studied by adaptive tracking and by reaction time. Performance was measured at 10 h, 13 h, 16 h, 19 h and 34 h after the overnight ingestion of the drug. There was no evidence of impaired performance on adaptive tracking from 10 h to 19 h, but enhanced performance (P = 0.001) was observed 34 h after ingestion. With reaction time an increase (P = 0.01) was observed 10 h and a decrease (P = 0.05) was observed 19 h after ingestion. 2 Effects in the monkey (Macaca mulatta) of methaqualone (20 and 30 mg/kg body weight) were studied by a delayed matching task in which total response time was measured. No consistent effects on matching behaviour or on total response time were observed 2 h after intraperitoneal injection. 3 The studies suggest that methaqualone hydrochloride may be a valuable hypnotic for occasional use by persons involved in skilled activity.

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