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Behavioural effects in rodents of methyl angolensate: a triterpenoid isolated from Entandrophragma angolense.

Authors
  • Amos, Samson
  • Orisadipe, Abayomi
  • Binda, Lucy
  • Emeje, Martins
  • Adesomoju, Akinbobola
  • Okogun, Joseph
  • Akah, Peter
  • Wambebe, Charles
  • Gamaniel, Karniyus
Type
Published Article
Journal
Pharmacology & toxicology
Publication Date
Aug 01, 2002
Volume
91
Issue
2
Pages
71–76
Identifiers
PMID: 12420795
Source
Medline
License
Unknown

Abstract

Behavioral effects of methyl angolensate were investigated in mice and rats. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behaviour, exploratory activity and apomorphine-induced climbing studies in mice were evaluated. The results revealed that methyl angolensate reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time in rats and attenuated amphetamine-induced stereotype behaviour in rats. Methyl angolensate also decreased exploratory activity in mice and reduced the rate of apomorphine-induced climbing in mice at the doses tested. It is suggested that methyl angolensate possesses some biologically active principles that are sedative in nature.

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