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Behavioral patterns under cholinergic control during development: lessons learned from the selective immunotoxin 192 IgG saporin.

Authors
Type
Published Article
Journal
Neuroscience & Biobehavioral Reviews
0149-7634
Publisher
Elsevier
Publication Date
Volume
27
Issue
4
Pages
377–384
Identifiers
PMID: 12946690
Source
Medline
License
Unknown

Abstract

The immunotoxin 192 IgG saporin (192 IgG-sap) offers a valuable tool to investigate the role of the developing basal forebrain cholinergic system in modulating behavioral functions in developing, as well as adult rats. After neonatal 192 IgG-sap lesions, rats display reduced ultrasonic vocalizations as neonates, deficits in passive avoidance learning as juveniles, and altered reactions to spatial novelty as adults. These data suggest that neonatal cholinergic depletion affects cognitive performance in juvenile and adult rats. Additionally, neonatal cholinergic depletion alters ultrasonic vocalizations, which could then alter establishing normal mother-infant relationships, and thus compound the pup's cognitive deficits. These findings underscore the importance of assessing behavior during ontogeny, as well as in adulthood.

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