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Behavioral effects of the cyclic cholecystokinin peptide analogue JMV-320.

Authors
  • Hadjiivanova, C
  • Kehayov, R
  • Petkov, V V
  • Amblard, M
  • Martinez, J
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
Jan 01, 1995
Volume
16
Issue
5
Pages
815–819
Identifiers
PMID: 7479320
Source
Medline
License
Unknown

Abstract

The in vivo effects of JMV-320 (a highly selective CCKB receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 micrograms/kg) impaired passive avoidance response 3 h after training and JMV-320 (1 and 10 micrograms/kg) decreased active avoidance response 24 h after training. The behavioral effects of JMV-320 resemble the effects of CCK-4 and suggest that in vivo JMV-320 acts as a CCKB receptor agonist.

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