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Evidence for a saturable clearance mechanism for111In-labeled monoclonal antibodies

Authors
Journal
International Journal of Nuclear Medicine and Biology
0047-0740
Publisher
Elsevier
Publication Date
Volume
12
Issue
4
Identifiers
DOI: 10.1016/0047-0740(85)90189-5

Abstract

Abstract We have studied the dose effect of 111In-labeled HDP-I on lung and liver uptake in rats. At low doses ( ⪡ 25 R g) the lung/liver ratios are quite low. Higher doses result in dramatically increased ratios, suggesting that an uptake or metabolic process in the liver was becoming saturated. These results are compared with those previously obtained with 125I-labeled HDP-1.

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