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In vitro and in vivo efficacy of lasalocid for treatment of experimental cryptosporidiosis

Authors
Journal
Veterinary Parasitology
0304-4017
Publisher
Elsevier
Publication Date
Volume
90
Issue
4
Identifiers
DOI: 10.1016/s0304-4017(00)00243-0
Keywords
  • Cryptosporidium Parvum
  • Lasalocid
  • In Vitro Viability
  • In Vivo Infectivity
  • Control Methods — Protozoa

Abstract

Abstract In vitro viability of purified Cryptosporidium parvum oocysts, exposed for 30, 60, 90 and 120 min to 0.27 mg/ml lasalocid suspension was evaluated by inclusion or exclusion of two fluorogenic vital dyes and an excystation technique. Continuously, preventive and curative efficacies at different doses (9, 6.75, 5.625 and 4.5 mg/kg body weight) and regimens of lasalocid against cryptosporidial infection were evaluated on an experimental neonatal mice model. In vitro assays demonstrated a decrease in the oocyst viability related to an increase in exposure time for exposure to the lasalocid suspension. The infection was eradicated when the suspension was administered with a dose of ≥6.75 mg/kg body weight. No apparent toxic effects were observed.

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