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The activation of γ aminobutyric acidAreceptors in the paraventricular nucleus of the hypothalamus reduces non-contact penile erections in male rats

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
314
Issue
3
Identifiers
DOI: 10.1016/s0304-3940(01)02287-x
Keywords
  • Non-Contact Penile Erections
  • γ Aminobutyric Acid
  • Muscimol
  • Baclofen
  • Paraventricular Nucleus Of The Hypothalamus
  • Rat
Disciplines
  • Biology

Abstract

Abstract Male rats show 4–6 penile erection episodes when put in the presence of an inaccessible receptive female. These non-contact penile erections were reduced dose-dependently by muscimol, a γ aminobutyric acid (GABA) A receptor agonist, when given into the paraventricular nucleus of the hypothalamus (0.1, 0.5, 1 and 2 μg). In contrast, baclofen, a GABA B receptor agonist (2 μg) was ineffective. Muscimol reduction of non-contact penile erections was not seen when male rats were pretreated with bicuculline methiodide (2 μg) given 5 min before muscimol into the paraventricular nucleus. Since muscimol injected into the paraventricular nucleus also prevents penile erection induced by drugs (e.g. apomorphine, oxytocin or N-methyl- d-aspartic acid), the present results show that an increased GABAergic activity in the paraventricular nucleus can impair the expression of penile erection induced not only by drugs but also by sexual physiological stimuli.

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