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Synthesis, biological and immunochemical properties of analogues of secretin and vasoactive intestinal peptide (VIP): The vasectrins

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
29
Issue
9
Identifiers
DOI: 10.1016/0024-3205(81)90390-8
Disciplines
  • Biology
  • Chemistry

Abstract

Abstract Three analogues of porcine secretin were synthesized with altered amino acid residues present in positions corresponding to those in porcine vasoactive intestinal peptide (VIP). We call these analogues vasectrins (VS). Problems in the syntheses of secretin and VIP are discussed. The biological and immunochemical behaviour of the analogues was studied. This allowed some conclusions about structure-activity relationships in the secretin/VIP family.

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