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Binding competition of okadaic acid derivatives to anti-okadaic acid antibody

Authors
Journal
Toxicon
0041-0101
Publisher
Elsevier
Publication Date
Volume
29
Issue
11
Identifiers
DOI: 10.1016/0041-0101(91)90129-f

Abstract

Abstract The serologic activities of structurally related okadaic acid derivatives have been determined. Binding of [ 3H]okadaic acid to rabbit anti-okadaic acid is inhibited with equal effectiveness by okadaic acid, dinophysistoxin-1, acanthifolicin, okadaic acid tetramethyl ether, and okadaic acid spiroketal II. Okadaic acid spiroketal I, which lacks the F- and G-rings of okadaic acid, inhibits serologic binding about 60 times less effectively. The F- and G-rings of okadaic acid may comprise part of the epitopes recognized by some of the polyclonal antibodies.

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