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Evidence for zolpidem efficacy in brain damage

Medpharm Publications Pty Ltd
Publication Date
  • Zolpidem
  • Brain Injury
  • Dormancy
  • Diaschisis
  • Biology
  • Medicine


Previous reports have shown that zolpidem could reverse semi-coma and improve cerebral perfusion after brain injury. Studies in animals have implicated omega 1 GABAergic action as reason for this improvement. Evidence for the efficacy of zolpidem in a wide range of brain pathology is reviewed here and the mechanism of zolpidem in brain injury is considered from the perspective of diaschisis and neurological dormancy after brain injury. Keywords: Zolpidem, brain injury, dormancy, diaschisis South African Family Practice Vol. 47(3) 2005: 49-50

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