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Regioselective bromination of phenols

DOI: 10.1016/s0926-9614(05)80006-1


Abstract Regioselective bromination of phenols gave 2-bromo-, 4-bromo-, 2,6-dibromo-2,4-dibromo, 2-bromo-6-substituted, 4-bromo-2-substituted and 2,4-dibromo-6-substituted phenols, respectively. Especially, 2-bromo-, 2,6-dibromo- and 2-bromo-6-substituted phenols which were prepared via long steps, were obtained in NBS-amine (primary and secondary) system in high yields under ordinary conditions. The scope and their mechanisms were discussed.

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