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Decreases in blood perfusion of the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis

BioMed Central
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Abstract BMC Psychiatry (2001) 1:2 BMC Psychiatry (2001) 1:2Research article Decreases in blood perfusionof the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis Tetsuro Naruo*1, Yoshiaki Nakabeppu2, Daisuke Deguchi1, Nobuatsu Nagai1, Junko Tsutsui1, Masayuki Nakajo2 and Shin-ichi Nozoe1 Address: 1Department of Psychosomatic Medicine, Kagoshima University Hospital, 8-35-1, Sakuragaoka, Kagoshima-City, Japan and 2Department of Radiology, Faculty of Medicine, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima-City, Japan E-mail: Tetsuro Naruo* - [email protected]; Yoshiaki Nakabeppu - [email protected]; Daisuke Deguchi - [email protected]; Nobuatsu Nagai - [email protected]; Junko Tsutsui - [email protected]; Masayuki Nakajo - [email protected]; Shin- ichi Nozoe - [email protected] *Corresponding author Abstract Background: It is possible that psychopathological differences exist between the restricting and bulimic forms of anorexia nervosa. We investigated localized differences of brain blood flow of anorexia nervosa patients using SPECT image analysis with statistic parametric mapping (SPM) in an attempt to link brain blood flow patterns to neurophysiologic characteristics. Methods: The subjects enrolled in this study included the following three groups: pure restrictor anorexics (AN-R), anorexic bulimics (AN-BP), and healthy volunteers (HV). All images were transformed into the standard anatomical space of the stereotactic brain atlas, then smoothed. After statistical analysis of each brain image, the relationships among images were evaluated. Results: SPM analysis of the SPECT images revealed that the blood flow of frontal area mainly containing bilateral anterior cingulate gyri (ACC) was significantly decreased in the AN-R group compared to the AN-BP and HV groups. Conclusions: These find

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