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Patients with Syndrome X have normal myocardial oxygenation and perfusion compared to normal volunteers: a 3 Tesla cardiovascular magnetic resonance imaging study

Authors
Journal
Journal of Cardiovascular Magnetic Resonance
1097-6647
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
13
Identifiers
DOI: 10.1186/1532-429x-13-s1-p126
Keywords
  • Poster Presentation
Disciplines
  • Biology
  • Medicine

Abstract

Patients with Syndrome X have normal myocardial oxygenation and perfusion compared to normal volunteers: a 3 Tesla cardiovascular magnetic resonance imaging study POSTER PRESENTATION Open Access Patients with Syndrome X have normal myocardial oxygenation and perfusion compared to normal volunteers: a 3 Tesla cardiovascular magnetic resonance imaging study Theodoros D Karamitsos1*, Ranjit Arnold1, Tammy J Pegg1, Jane Francis1, Ruairidh K Howells1, Matthew D Robson1, Stefan Neubauer1, Michael Jerosch-Herold2, Joseph B Selvanayagam3 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Objective The aim of our study was to assess regional myocardial perfusion and oxygenation in patients with Syndrome X and in normal volunteers, using cardiovascular magnetic resonance (CMR) imaging at 3 Tesla. Introduction The pathophysiology of chest pain in patients with Syn- drome X remains controversial. Previous studies using nuclear techniques or CMR to assess myocardial perfu- sion have shown conflicting results. Advances in perfu- sion imaging with CMR now enable absolute quantification of regional myocardial blood flow. Further- more, blood oxygenation level-dependent (BOLD) CMR provides the unprecedented capability to assess regional myocardial oxygenation. We hypothesized that the com- bined assessment of regional perfusion and oxygenation with CMR could clarify whether patients with cardiac Syndrome X show evidence of myocardial ischemia (reduced perfusion and oxygenation) during vasodilator stress compared to normal volunteers. Methods 18 patients (15 women) with Syndrome X (chest pain, abnormal exercise treadmill test, normal coronary angio- gram but no hypertension, diabetes or other causes of microvascular dysfunction) and 14 age and sex-matched normal volunteers (11 women) underwent CMR scanning at 3 Tesla. Myocardial function (cine CMR), scar (late gadolinium enhancement), perfusion and oxygenation were assessed. For perfusion, 2-3 short axis slices

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