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Effect of dentate stimulation on neuronal activity in the globus pallidus

Experimental Neurology
Publication Date
DOI: 10.1016/0014-4886(69)90023-5


Abstract Experiments were carried out in anesthetized cats with stimulating electrodes placed in the dentate nuclei and recording microelectrodes in the globus pallidus. These have led to the following observations and conclusions: The spontaneous activity recorded from a given cell in the globus pallidum could be fast and, from another, slow in its discharge frequency under similar experimental conditions. The discharge frequency of some of these cells could be decreased or increased by contralateral or ipsilateral dentate stimulation at frequencies of 10 or 100/sec, but more effectively at 100/sec. The latency of the increased or decreased activity after stimulation varied from 100 to 500 msec. As the increased or decreased activity once began, it slowly returned to its prestimulation level in 2.0–2.5 sec after the termination of the stimulation. A single stimulus applied to the dentate nucleus could evoke a response in a contralateral pallidal cell with consistent latency of 20 msec. A single stimulus applied to the dentate nucleus could evoke a suppression of spike discharge recorded from a contralateral pallidal neuron with a latency of 100–230 msec and for periods of 300–900 msec. The above observations on the responsiveness to stimulation could be obtained only from about 5% of all the cells in the globus pallidus. It is, therefore, concluded that the dentate nucleus has direct connections, though relatively few, with the contralateral globus pallidus and multisynaptic pathways to the contralateral and ipsilateral globus pallidus.

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